In the United States, United Kingdom, Canada, Australia and Lithuania this drug cannot be sold over-the-counter and must be administered only with a prescription. It is commonly available over-the-counter in Mexico and other areas of Latin America, at the pharmacist's discretion. It is not approved for use via oral in Belgium and Spain.
Основные причины вывода или ограничения использования (гастротоксичность, нефротоксичность, гематотокичность):
Can cause peptic ulcers, GI bleeding, and/or perforation.1 Contraindicated in patients with active peptic ulcer disease, recent GI bleeding or perforation, or a history of peptic ulcer disease or GI bleeding.
Serious GI events can occur at any time and may not be preceded by warning signs and symptoms.198 Geriatric individuals are at greater risk for serious GI events.198 (See GI Effects under Cautions.)
Contraindicated in patients with advanced renal impairment and those at risk of renal failure because of volume depletion.
Inhibits platelet function.1 Contraindicated in patients with suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, or incomplete hemostasis and in patients at a high risk of bleeding.
Contraindicated as prophylactic analgesic before major surgery; contraindicated as intraoperative analgesic during procedures where hemostasis is critical.1 Increased risk of bleeding in these patients.
Contraindicated for the treatment of pain in the setting of CABG surgery. Possible increased risk of serious (sometimes fatal) cardiovascular thrombotic events (e.g., MI, stroke).198 Risk may increase with duration of use.198 Individuals with cardiovascular disease or risk factors for cardiovascular disease may be at increased risk.198 (See Cardiovascular Effects under Cautions.)
А в остальном, Друг Человека, все хорошо! все хорошо?